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上饶韩美整形美容医院整形美容中国指南上饶祛痣

2019年07月23日 23:59:07
来源:四川新闻网
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上饶韩美整形医院祛雀斑好不好上饶广丰区自体脂肪移植丰胸哪家好Okay.好了So what is the daf-2 gene?那么daf-2基因到底是什么?Well as you know, genes, which are part of the DNA,正如大家所知,基因是DNA的一部分theyre instructions to make a protein that does something.它们是经编码的指令,用于制造特定功能的蛋白质And the daf-2 gene而daf-2基因的编码encodes a hormone receptor.对应了一类激素受体So what you see in the picture there图片上可以看到的是一个细胞is a cell with a hormone receptor in red以及红色的激素受体punching through the edge of the cell.插在细胞的边缘So part of it is like a baseball glove.受体的一部分就像棒球手套Part of its on the outside,外面的部分伸出去and its catching the hormone as it comes by in green.当绿色的激素靠近的时候抓住这个激素And the other part is on the inside另外的部分在细胞内where it sends signals into the cell.向细胞传递信号Okay, so what is the daf-2 receptor好了,那daf-2受体向细胞里telling the inside of the cell?传了什么样的信号?I just told you that, if you make a mutation in the daf-2 gene cell,我刚刚说过,如果突变细胞里的daf-2基因that you get a receptor that doesnt work as well;就能得到一个功能不太给力的受体the animal lives longer.并且动物的寿命变长So that means that the normal function of this hormone receptor这就意味着这个激素受体的正常功能is to speed up aging.是加速衰老Thats what that arrow means.就是图上箭头的意思It speeds up aging. It makes it go faster.总之会让衰老来得更快So its like the animal has the grim reaper inside of itself,就好像动物的身体里有个死神speeding up aging.一直在加速衰老So this is altogether really, really interesting.总之这个结论就非常有趣了It says that aging is subject to control by the genes,结论就是,衰老是受基因控制的and specifically by hormones.具体讲是受激素控制的So what kind of hormones are these?这些激素又是什么样的激素呢?Theres lots of hormones. Theres testosterone, adrenalin.有很多种激素,比如睾酮和肾上腺素You know about a lot of them.你肯定知道很多These hormones are similar这些激素和我们to hormones that we have in our bodies.身体里的激素差不多The daf-2 hormone receptordaf-2激素受体is very similar to the receptor与胰岛素和IGF-1的受体for the hormone insulin and IGF-1.非常像Now youve all heard of at least insulin.至少大家都听说过胰岛素Insulin is a hormone that promotes the uptake of nutrients胰岛素是一种激素,在饭后促进into your tissues after you eat a meal.身体的组织吸收营养And the hormone IGF-1 promotes growth.而IGF-1这种激素促进生长So these functions were known for these hormones for a long time,这些激素的功能是我们长久以来就知道的but our studies suggested但是我们的研究似乎暗示that maybe they had a third function that nobody knew about --有可能有第三种我们未知的功能--maybe they also affect aging.或许也能影响衰老And its looking like thats the case.而且看起来似乎的确是这样So after we made our discoveries with little C. elegans,所以在我们对秀丽隐杆线虫的小发现之后people who worked on other kinds of animals研究其他动物的研究员提出问题started asking, if we made the same daf-2 mutation,如果在其他动物身上造成同样的daf-2变异the hormone receptor mutation, in other animals,也就是激素受体变异will they live longer?它们也会更长寿吗?And that is the case in flies.在苍蝇身上,是的If you change this hormone pathway in flies, they live longer.如果改变苍蝇体内这种激素的传递方式,它们就会长寿And also in mice -- and mice are mammals like us.在老鼠身上也一样--而老鼠是像我们一样的哺乳动物So its an ancient pathway,所以其实这是一个古老原始的传递方式because it must have arisen a long time ago in evolution一定在很久以前的进化进程中就出现了such that it still works in all these animals.这样才会让所有动物身上都有这样的效应And also, the common precursor also gave rise to people.而且,这些共同的实验前兆也引向到人类的衰老问题上So maybe its working in people the same way.所以或许在人类中也同样适用And there are hints of this.确实有迹象表明这点So for example, there was one study that was done比如,曾有人针对纽约市in a population of Ashkenazi Jews in New York City.阿什肯纳兹犹太人做了研究And just like any population,和其他人群一样most of the people live to be about 70 or 80,大多数人活到70或80岁but some live to be 90 or 100.但是有的人活到了90或100岁And what they found研究人员发现was that people who lived to 90 or 100活到90或100岁的人were more likely to have daf-2 mutations --更有可能有daf-2变异--that is, changes in the gene也就是说,编码了IGF-1受体that encodes the receptor for IGF-1.的那段基因产生了变异And these changes made the gene not act as well这些变异让基因行为与正常基因相比as the normal gene would have acted.效果更弱一些It damaged the gene.相当于基因受损了So those are hints所以这些迹象suggesting that humans are susceptible表明人类对于控制衰老的激素to the effects of the hormones for aging.所带来的效果是很敏感的So the next question, of course, is:所以接下来的问题当然就是Is there any effect on age-related disease?这对与年龄相关的老龄病有影响吗?As you age, youre much more likely因为当年龄变老的时候,我们就更可能to get cancer, Alzheimers disease,患上癌症,老年痴呆症heart disease, all sorts of diseases.心脏病,等等一系列的疾病It turns out that these long-lived mutants结果这些长寿的变异体are more resistant to all these diseases.对于这些疾病更有抵抗能力They hardly get cancer,他们几乎不得癌症and when they do its not as severe.就算得了,也并不如本来应该的那样严重So its really interesting, and it makes sense in a way,所以这很有趣,而且这样想来确实有道理that theyre still young,他们的身体还年轻so why would they be getting diseases of aging until their old?所以为什么只有到老年,他们会得衰老的一些疾病So it suggests这就启发我们that, if we could have a therapeutic or a pill to take如果有疗法或者药片to replicate some of these effects in humans,来对人体复制这些减缓衰老的效应maybe we would have a way也许我们就有办法of combating lots of different age-related diseases一下子抵抗所有种类的all at once.老龄病201508/390452Hi everybody. Seven years ago, the American auto industry was on the brink of collapse. Plants were closing. Hundreds of thousands of workers were getting laid off from jobs that had been their ticket to a middle-class life. And as the pain sp across the country, another one million Americans would have lost their jobs in the middle of the worst economic crisis of our lifetimes.大家好。七年前,美国的汽车产业面临崩溃。工厂倒闭,成千上万的工人失去工作,同时也失去了跻身中产阶级的门票。随着这种趋势蔓延下去,我们遭遇了此生最严重的经济危机,100多万人失去了工作。Some said it was too late to turn things around. But I refused to turn my back on so many of the workers that Id met. Instead, I placed my bet on American workers. I placed my bet on American manufacturing. In exchange for help, we demanded responsibility. We said the auto industry would have to truly change, not just pretend that it did. We got labor and management to settle their differences. We got the industry to retool and restructure. Everyone had some skin in the game.有人说,太晚了,局势无法扭转了。但我亲眼见过这些工人,我拒绝放弃他们。相反,我选择与美国的工人们同舟共济。我选择与美国的制造业同舟共济。为了得到帮助,我们需要负起责任。我们说过,汽车产业需要进行真正的变革,而不是做做假把式。我们让职工与管理层进行对话,解决分歧。我们对整个行业进行升级改造。每个人都是这场运动中的一分子。Our plan wasnt popular. Critics said it was a “road to socialism,” or a “disaster” waiting to happen. But Id make that bet again any day of the week. Because today, the American auto industry is back. Since our plan went into effect, our automakers have added more than 640,000 new jobs. Weve cut the Detroit-area unemployment rate by more than half. The Big Three automakers are raising wages. Seven years ago, auto sales hit a 27-year low. Last year, they hit an all-time high.我们的计划一开始并不受欢迎。批评人士说,这是“社会主义道路”,或是迟早要发生的“灾难”。但我每一周、每一天我都下定决心要坚持下去。因为今天,美国的汽车产业又回归了。当我们的政策产生效果之后,汽车生产商共增加了64万个工作岗位。我们将底特律地区的失业率降低了一半以上。三大汽车生产商也纷纷提高工资标准。七年前,汽车销量创下27年的最低值,而去年,他们却创下有史以来的新高。Later this month, Ill visit the Detroit Auto Show to see this progress firsthand. Because I believe that every American should be proud of what our most iconic industry has done.这个月末,我会参加底特律车展,以第一视角看看我们取得的成绩。因为我相信,每个美国人都应该为美国的标志性行业的取得的成就而感到自豪。Its not unlike what America overall has done these past seven years. Our businesses are now on a 70-month streak of job creation, with more than 14 million new jobs in all. Weve revamped our schools and the way we pay for college. Weve made historic investments in clean energy and put ourselves on a path to a low-carbon future. Weve brought more than 17 million Americans into our health care system, seen health care prices grow at the lowest rate in fifty years, and covered more than 90 percent of our people for the very first time. Weve even cut our deficits by nearly 75 percent in the process.回顾美国各行各业在过去七年里所做的事情,不能不让人惊叹。我们的企业创下连续79个月就业增长的记录,共新增1400多万个就业岗位。我们对学校进行改革,改变了大学学费的付方式。我们对新能源领域进行了历史性的投资,低碳走向未来。我们让1700多万美国人民加入医保体系,看到医保价格增长速度降到50年来的最低水平,而且首次让90%以上的人都得到保障。与此同时,我们将财政赤字削减了将近75%。The point is America can do anything. Even in times of great challenge and change, our future is entirely up to us. Thats been on my mind while Im writing my final State of the Union Address. And on Tuesday, Im going to talk about the choices we have to make to set this country firmly on an even better, brighter course for decades to come.关键点是,美国能够做好任何事情。即便面临巨大的挑战和变革,我们的未来依然完全掌握在我们自己手中。在我准备我最后一次国情咨文演讲的过程中,这个概念一直浮现在我的脑海中。下周二,我会谈谈我们需要做出的选择,为了赢得更美好、更光明的未来我们要为这个国家打下坚实的基础。Thanks, and have a great weekend.谢谢大家。祝周末愉快!201601/422263上饶婺源县去眼袋手术多少钱

信州区妇幼保健人民中医院打瘦腿针多少钱上饶市肿瘤医院绣眉手术多少钱Lets just look at a few of these strategies.让我们来看看其中一些策略吧:First off, its really interesting to see,to actually visually see, how quick the gay rights movement has made its gains,if you look at a few of the major events on a timeline of both freedom movements. 首先,非常有趣地,如果你们回顾下,漫漫自由路上的一些主要事件,你们会发现至少表面上如此同性恋权利运动,是呈何等飞速在增长啊!Now, there are tons of milestones in the civil rights movement,but the first one were going to start with is the 1955 Montgomery bus boycott. 民权运动,已知的,就有数以万计的里程碑事件。现在,让我们从,1955年蒙哥马利公共汽车抵制事件说起。This was a protest campaign against Montgomery, Alabamas segregation on their public transit system,and it began when a woman named Rosa Parks refused to give up her seat to a white person. 这场运动旨在反对,亚拉巴马州,蒙哥马利市对于公共交通系统的,种族隔离政策。它的导火索是,一位叫Rosa Parks的女士,拒绝为一位白人让座。The campaign lasted a year,and it galvanized the civil rights movement like nothing had before it. 此场运动持续一年,它前所未有地,激励了民权运动And I call this strategy the Im tired of your foot on my neck strategy.我称此策略为:我不再匍匐于你跟前。So gays and lesbians have been in society since societies began,but up until the mid-20th century,homosexual acts were still illegal in most states. 男同及女同自社会产生起,即与之共生。但直到20世纪中期之前,同性恋行为在大部分的州依然违法。So just 14 years after the Montgomery bus boycott,a group of LGBT folks took that same strategy. 所以,仅在蒙哥马利公交车抵制事件后14年,即1969年,同性恋社区的一伙人,就采取了相同的策略,Its known as Stonewall, in 1969,and its where a group of LGBT patrons fought back against police beatings at a Greenwich Village bar that sparked three days of rioting. 即我们所称的石墙事件。三天骚乱后,星星之火,终于点燃。在格林尼治酒吧的同性恋顾客,以暴制暴,勇敢反抗警察围捕。Incidentally, black and latino LGBT folks were at the forefront of this rebellion,and its a really interesting example of the intersection of our struggles against racism, homophobia, gender identity and police brutality.巧合的是,于此役,黑人和拉丁美洲的同性恋者被推向统一战线。这是我们反抗种族主义,同性恋恐惧症,性别歧视,及政策偏袒的鲜明之例。After Stonewall happened, gay liberation groups sprang up all over the country,and the modern gay rights movement as we know it took off. 石墙事件后不久,同性恋自由组织如雨后春笋般,在全国涌现。并最终发展成我们如今知晓的,同性恋权利运动。So the next moment to look at on the timeline is the 1963 March on Washington.接着,我们要回顾的,是1963年的向华盛顿进军。This was a seminal event in the civil rights movement and its where African-Americans called for both civil and economic justice.这是民权运动中,具有里程碑意义的事件,这是非裔美国人呼唤权利与财政公平之始。And its of course where Martin Luther King elivered his famous I have a dream speech,but whats actually less known is that this march was organized by a man named Bayard Rustin. 这也是马丁路德金发表著名的《我有一个梦想》之处。但鲜为人知的是,这次游行,是由一个叫Bayard Rustin的人组织的。Bayard was an out gay man, Bayard and hes considered one of the most brilliant strategists of the civil rights movement.是一名出柜了的同性恋,也被认为是民权运动中,最杰出的决策者之一。He later in his life became a fierce advocate of LGBT rights as well, and his life is testament to the intersection of the struggles.他后来,也成为了同性恋权利运动的热情拥护者。他的一生,亦明了民权运动和同性恋权利运动的交集。The March on Washington向华盛顿进军is one of the high points of the movement,and its where there was a fervent belief that African-Americans too could be a part of American democracy.是此一运动(民权运动)的巅峰之一,同时,也体现了非裔美国人也是美国民主制度一部分的热切信念。I call this strategy the We are visible and many in numbers strategy.我称这个策略为我们聚合众生,将被见。Some early gay activists were actually directly inspired by the march,and some had taken part.有些早期的同性恋活动家,实际上直接被这一游行鼓舞。他们中的一些人甚至参加了这一游行。Gay pioneer Jack Nichols said,We marched with Martin Luther King,seven of us from the Mattachine Society,which was an early gay rights organization and from that moment on, we had our own dream about a gay rights march of similar proportions. 同性恋权利运动的先驱者Jack Nichols道:我们同马丁路德金一起游行,我们中有七个人来自马特辛社区,一个早期同性恋组织-自此,我们梦想同性恋权利运动,如它般卓尔不群。Several years later, a series of marches took place,each one gaining the momentum of the gay freedom struggle. 几年后,出现了一系列的游行每一次都在为同性恋自由的抗争积蓄能量。The first one was in 1979,and the second one took place in 1987. 第一次是1979年,然后第二次是1987年。The third one was held in 1993.第三次游行发生在1993年。Almost a million people showed up,and people were so energized and excited by what had taken place,they went back to their own communities and started their own political and social organizations,further increasing the visibility of the movement. 有近百万人参与,人们因所发生的欢欣鼓舞,他们回到各自的社区,组建自己的政治性组织,或社会性组织,以求使这一运动遍及大众视野。201503/366078上饶横峰县自体脂肪隆鼻价格The best scientific exploration sounded like a fairytale.当时最好的科学理论就像是童话故事。My second grade teacher Mrs. McGonigle it to us.我的二年级老师麦戈尼格尔女士告诉我们。The dinosaurs had small brains. They were stupid.恐龙的脑非常小 它们很愚蠢。So mice and bats beat up the dinosaur and took their food.老鼠和蝙蝠打败了恐龙 抢走了它们的食物。Really.真的。But in my lifetime, everybody.但在我一生的时间里。We discovered the meteor impact crater near Chicxulub New Mexico.我们在新墨西哥希克苏鲁伯发现了巨大的陨石坑。The ejecta from that collision shot out over a diameter bigger than the earth itself.碰撞产生的喷射物 直径要比地球本身还要大。It went halfway to the moon.达到了地月距离的一半。It was like science fiction except that it was real.听起来就像科幻小说 不过它是真实的。And by the way 顺便说下。As a result of that discovery in last years airburst over Chelyabinsk, Russia.去年俄罗斯车里雅宾斯克上空的空中爆炸。And the very near miss of asteroid 2012 DA14.以及小行星2012 DA14的擦肩而过。People were at last appreciating the astonishing threat of an asteroid impact.让人们开始意识到小行星撞击的可怕威胁。You all are the first generation of.你们将成为第一代。Engineers, scientists, educators and foreign-policy wonks.工程师 科学家 教育者 外交政策制定者。Who can get humankind to do something about an incoming asteroid.来让人类对可能的小行星撞击做点什么。It is the only preventable natural disaster.这是唯一可以避免的自然灾害。What are you going to do? Youre going to have a kinetic impactor.怎么做呢 你可以发明一个动力撞击器。Like solar sail spacecraft.或是太阳帆太空船。A swarm of rock vaporizing lasers in space.可以发射让岩石蒸发的激光。Its going to have to be something someday.某天 总会有这类东西。So we are counting on you.我们需要指望你们。Im claiming that there will be similar world changing discoveries.我敢肯定 在你们这一生中。In the coming years in your life.世界肯定会发生类似变革。For example recently weve come to know that.例如最近 我们开始知道。The universe is bigger than anyone ever thought.宇宙比以往任何人想象的都要大。Not only that.此外。Its getting bigger faster, its expansion is accelerating.它还在越来越快地变大 膨胀正在加速。 201510/406260上饶上饶县镭射去痘印价格

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